Lycopene prevents cisplatin-induced liver tissue damage, without affecting concentrations of TNF-α or iNOS/NO inflammatory pathway

Introduction Liver inflammatory response occurring after toxic chemicals injection, such as cisplatin, causes the aggravation in liver damage. Lycopene, a carotenoid, has previously been proven to possess antioxidant, antiinflammatory and antiapoptotic properties. This study objective was evaluate for first time protective effects of lycopene cisplatin-induced damage based on disturbances serum tissue parameters. Also, confirm extent changes inflammation studied tissue, microscopic analysis will be performed. Material methods Wistar rats were divided into four experimental groups: (I) control; (II) (2 mg/kg); (III) cisplatin (10 mg/kg) (IV) cisplatin-treated 10 mg/kg, respectively) animals. After experiment, we associated parameters (ALT, AST, γ-GT) (NO TNF-α concentrations, myeloperoxidase iNOS activity, well CD68 expression). Results Application prevented rise evaluated induced by while at same it did not cause any harmful effect itself. alone or combination with decreased values all Conclusions We can conclude that does prevent decalin seen application, however, prevents arising from this cytostatic application.